ANTIBACTERIALS >CEPHALOSPORINS > EXTACEF® - XL
For the use of a Registered Medical Practitioner, a Hospital or a Laboratory only.
COMPOSITION
EXTACEF- XL 375 mg. INJ.
Each Vial Contains:
Sterile Ceftriaxone Sodium IP Equivalent to Anhydrous Ceftriaxone 250 mg
Sterile Sulbactam Sodium USP Equivalent to Sulbactam 125 mg
 
EXTACEF- XL 1.5g INJ.
Each Vial Contains:
Sterile Ceftriaxone Sodium IP Equivalent to Anhydrous Ceftriaxone 1000 mg
Sterile Sulbactam Sodium USP Equivalent to Sulbactam 500 mg
 
INDICATIONS
EXTACEF-XL is indicated for susceptible pathogens causing: Complicated intra-abdominal infections.
  • Recurrent UTIs since sensitivity of E coli to ceftriaxone alone maybe 74%. This is in view of ESBL elaborated by E coli.
  • Endocarditis due to ESBL elaborated by the pathogens.Confirmed staphylococcal, K pneumoniae or P mirabilis infections. Acinetobacter (banumannii) spp infections like nosocomial meningitis. Gram negative infections in ICU patients: 97% maybe cross-resistant to ceftriaxone! (because of marked loss of ceftriaxone's activity on account of production of class A and C ß-lactamases).
  • Pediatric respiratory infections because H influenzae is a common pathogen, and nearly 15% are ß-lactamases producers
  • Critically ill patients with any ceftriaxone-susceptible infecting pathogen/s
  • Elderly patients with comorbid illness
  • Neonatal septicemia - since 29% of the pathogens are staphylococci and sensitivity to ceftriaxone alone is 69%.
  • Nosocomial infections since these bacteria are frequently ß-lactamases producers (especially ESBL).
  • Necrotizing surgical site infection
  • Resistant plague infection.
DOSAGE AND ADMINISTRATION
Parenteral (IM/IV): Adults: 1-2 gm ceftriaxone per day as EXTACEF-XL Inj IM / IV once daily (or in equally divided doses twice a day) depending up on the type and severity of the infection. The total daily dose of ceftriaxone should not exceed 4 gm.

EXTACEF-XL Inj therapy should generally be continued for at least 2 days after the signs and symptoms of infection have disappeared. The usual duration is 4 to 14 days; in complicated infections longer therapy may be required. While treating infections caused by Streptococcus pyogenes, the therapy should be continued for at least ten days.

SURGICAL PROPHYLAXIS: 1 gm ceftriaxone single dose as EXTACEF-XL Inj IV ½ to 2 hours before surgery.

UNCOMPLICATED GONOCOCCAL INFECTIONS: 250 mg ceftriaxone single dose as EXTACEF-XL Inj IM.

Children: 50 to 75 mg ceftriaxone/kg body-weight per day (not exceeding 2 gm) as EXTACEF-XL Inj IM / IV in 2 divided doses every 12 hours.

MENINGITIS: 100 mg ceftriaxone/kg body-weight per day (not exceeding 4 gm) as EXTACEF-XL Inj IV initially; thereafter, 100 mg ceftriaxone/kg body-weight per day (maximum 4 gm/day) as EXTACEF-XL Inj IV as single dose or in equally 2 divided doses every 12 hours for 7-14 days.

ACUTE BACTERIAL OTITIS MEDIA: 50 mg ceftriaxone/kg body-weight per day (not exceeding 1 gm) as EXTACEF-XL Inj IM single dose.
HOW SUPPLIED
Twin pack: Vial & srterile water for injection as a diluent.