Extacef XL Inj

EXTACEF® – XL

CEPHALOSPORINS
For The Use Of A Registered Medical Practitioner, A Hospital Or A Laboratory Only.

COMPOSITION
EXTACEF- XL 375 mg. INJ.
Each Vial Contains:
Sterile Ceftriaxone Sodium IP Equivalent to Anhydrous Ceftriaxone	250 mg
Sterile Sulbactam Sodium USP Equivalent to Sulbactam	125 mg

EXTACEF- XL 1.5g INJ.
Each Vial Contains:
Sterile Ceftriaxone Sodium IP Equivalent to Anhydrous Ceftriaxone	1000 mg
Sterile Sulbactam Sodium USP Equivalent to Sulbactam	500 mg

INDICATIONS
EXTACEF-XL is indicated for susceptible pathogens causing: Complicated intra-abdominal infections. Recurrent UTIs since sensitivity of E coli to ceftriaxone alone maybe 74%. This is in view of ESBL elaborated by E coli. Endocarditis due to ESBL elaborated by the pathogens.Confirmed staphylococcal, K pneumoniae or P mirabilis infections. Acinetobacter (banumannii) spp infections like nosocomial meningitis. Gram negative infections in ICU patients: 97% maybe cross-resistant to ceftriaxone! (because of marked loss of ceftriaxone’s activity on account of production of class A and C ß-lactamases). Pediatric respiratory infections because H influenzae is a common pathogen, and nearly 15% are ß-lactamases producers Critically ill patients with any ceftriaxone-susceptible infecting pathogen/s Elderly patients with comorbid illness Neonatal septicemia – since 29% of the pathogens are staphylococci and sensitivity to ceftriaxone alone is 69%. Nosocomial infections since these bacteria are frequently ß-lactamases producers (especially ESBL). Necrotizing surgical site infection Resistant plague infection.
DOSAGE AND ADMINISTRATION
Parenteral (IM/IV): Adults: 1-2 gm ceftriaxone per day as EXTACEF-XL Inj IM / IV once daily (or in equally divided doses twice a day) depending up on the type and severity of the infection. The total daily dose of ceftriaxone should not exceed 4 gm. EXTACEF-XL Inj therapy should generally be continued for at least 2 days after the signs and symptoms of infection have disappeared. The usual duration is 4 to 14 days; in complicated infections longer therapy may be required. While treating infections caused by Streptococcus pyogenes, the therapy should be continued for at least ten days. SURGICAL PROPHYLAXIS: 1 gm ceftriaxone single dose as EXTACEF-XL Inj IV ½ to 2 hours before surgery. UNCOMPLICATED GONOCOCCAL INFECTIONS: 250 mg ceftriaxone single dose as EXTACEF-XL Inj IM. Children: 50 to 75 mg ceftriaxone/kg body-weight per day (not exceeding 2 gm) as EXTACEF-XL Inj IM / IV in 2 divided doses every 12 hours. MENINGITIS: 100 mg ceftriaxone/kg body-weight per day (not exceeding 4 gm) as EXTACEF-XL Inj IV initially; thereafter, 100 mg ceftriaxone/kg body-weight per day (maximum 4 gm/day) as EXTACEF-XL Inj IV as single dose or in equally 2 divided doses every 12 hours for 7-14 days. ACUTE BACTERIAL OTITIS MEDIA: 50 mg ceftriaxone/kg body-weight per day (not exceeding 1 gm) as EXTACEF-XL Inj IM single dose.
HOW SUPPLIED
Twin pack: Vial & srterile water for injection as a diluent.

Category: ANTI BACTERIALS D.P